Rui-qin Yao, Ph.D., Professor

Dept. Neurobiology & Cell Biology                               
School of Basic Medical Sciences,
Xuzhou Medical University,
Xuzhou, 221004, P.R. China

   
n  Biography
Prof. Ruiqin Yao obtained her B.Sc. in Biology from Xuzhou Normal University in 1998. Then she moved to Dept. of Neurobiology & Anatomy of Xuzhou Medical College as a yong teacher. She started her research on neural stem cells and obtained her Master degree in Neurobiology in 2003.  After she earned her Ph.D. in Neurobiology from Xuanwu Hospital of Capital Medical University in 2008, she came back to Xuzhou Medcial College and continued her teaching job and research on demyelination disease in CNS. From 2011, she did his post-doctoral research with Prof. Kim Wang-soo in the Department of Molecular Neurobiology Laboratory at the Harvard Medical School. Since Dec. 2012, she has been working as a professor in Department of Cell Biology and Neurobiology, Xuzhou Medical University.

n  Grant Support

Principal Investigator:

1.      Olig2-GFP knock-in human embryonic stem cells-derived and Olig2/Nkx2.2 overexpressed oligodendrocyte progenitors for application in demylination diseases. National Natural Science Foundation of China. National Natural Science Foundation of China (NSFC). No. 81271345, 2013.01-2016.12.

2.      The effects and mechanism of Cornel iridoid glycoside on neurogenesis and angiogenesis in stroke model rat. National Natural Science Foundation of China (NSFC). No. 30801526, 2009.01-2011.12.  Finished.

3.      Molecular mechanisms of miR-219 and Dnmt3a regulation of MCT1 participation in oligodendrocyte differentiation and myelination.Natural Science Foundation of Jiangsu Province. No. BK20131132, 2013.09-2016.12. 

4.      The effects and mechanism of quercetin on the differentiation of oligodendrocyte precursor cells and protection of ischemia-hypoxia neonatal rat model. Science Foundation of Jiangsu Province. No. 09KJD310010, 2009.09-2011.12.

n  Selected Publications((* represent Corresponding author)
1.         Qu X, Zhou J, Wang T, Han J, Ma L, Yu H, Geng D, Fan H, Zhang Q, Hua F, Yao R（corresponding author）. MiR-30a inhibits Th17 differentiation and the demyelination of EAE mice by targeting IL-21R. Brain Behav Immun.2016 Mar 19. pii: S0889-1591(16)30061-7 doi: 10.1016/j.bbi.2016.03.016. [IF: 5.988]
2.         Qu X, Guo R, Zhang Z, Ma L, Wu X, Luo M, Dong F, Yao R*. bFGF Protects Pre-oligodendrocytes from Oxygen/Glucose Deprivation Injury to Ameliorate Demyelination. Cell Mol Neurobiol. 2015;35(7):913-20. [IF: 2.293]
3.         Kim TG, Yao R, Monnell T, Cho JH, Vasudevan A, Koh A, Kumar T P, Moon M, DattaD, Bolshakov VY, Kim KS, Chung. S. Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudual modulation. Stem cells. 2014 ;32(7):1789-804. [IF: 6.523]
4.         Yu ZQ, Zhang BL, Ni HB, Liu ZH, Wang JC, Ren QX, Mo JB, Xiong Y, Yao RQ, Gao DS*. Hyperacetylation of histone H3K9 involved in the promotion of abnormally high transcription of gdnf gene in glima cells. Mol Neurobiol. 2014;50(3):914-22. [IF: 5.137]
5.         Zhang BL, Ni HB, Liu J, Lei Y, Li H, Xiong Y, Yao R, Yu ZQ, Gao DS*. Egr-1 participates in abnormally high gdnf gene transcription mediated by histone hyperacetylation in glioma cells. Biochim Biophys Acta. 2014;1839(11):1161-9
6.         Ruiqin Yao*,Bei Wang, Chuanlu Ren,Xuebin Qu,Mengjiao Luo, Qiang Zhang, Huiping Wang,Fuxing Dong,Xiuxiang Wu, Lihua Yang and Hongli Yu. Olig2 facilitates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro. Development Growth & Differentiation, 2014, 56(7):511-7 [IF: 2.397]
7.         Xuebin Qu, Dashi Qi, Fuxing Dong, Bei Wang, Rui Guo, Mengjiao Luo, Ruiqin Yao*.Quercetin improves hypoxia-ischemia induced cognitive deficits via promoting remyelination in neonatal rat. Brain Res. 2014, 1553:31-40. [IF: 2.879]
8.         Xiuxiang Wu, Xuebin Qu, Qiang Zhang，Fuxing Dong, Hongli Yu, Chen Yan, Dashi Qi, Meng Wang, Xuan Liu  and Ruiqin Yao*. Quercetin Promotes Proliferation and Differentiation of Oligodendrocyte Precursor Cells after Oxygen/Glucose Deprivation-induced Injury. Cell Mol Neurobiol (2014) 34(3):463-471 [IF: 2.293]
9.         Yao RQ*, Qi DS, Yu HL, Liu J, Yang LH, Wu XX. Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB -PI3K/Akt signaling pathway. Neurochem Res. 2012; 37(12):2777-2786.  [IF: 2.125]
10.      X-Q Wang, R-Q Yao*, X Liu, J –J Huang, D-S Qi, L-H Yang. Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of PI3K/Akt signaling pathway. Brain Res Bull. 2011 86(3-4):277-84.  [IF: 2.935] 
11.      Ruiqin Yao, Lan Zhang, Xiaoli Li, Lin Li. Effects of Epimedium flavanoids on proliferation and differentiation of neural stem cells in vitro. Neurol Res. 2010; 32 (7):736-42   [IF: 1.634] 
12.      R.-Q. Yao，L. Zhang，W.Wang， L. Li. Cornel iridoid glycoside promotes neurogenesis and angiogenesis and improves neurological function after focal cerebral ischemia in rats. Brain Res Bull. 2009 ,79(1):69-76.  [IF: 2.935]